東京大学先端科学技術研究センター 代謝医学分野 酒井研究室

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助教 榊原 伊織(さかきばら いおり)

榊原伊織

略歴

2002年3月 東京大学 農学部 応用生物学専修卒業
2004年3月 東京大学大学院 農学生命科学研究科 生産・環境生物学専攻 修士課程修了
2007年3月 東京大学大学院 工学系科学研究科 先端学際工学専攻 博士課程修了
2007年4月 東京大学 先端科学技術研究センター 研究員
2009年4月 仏国Cochin Institute ポスドク
2014年4月 愛媛大学プロテオサイエンスセンター病態生理解析部門 助教
2017年5月 東京大学先端科学技術研究センター代謝医学分野 助教 現在に至る

代表論文

  1. Sakakibara, I., Wurmser, M., Dos Santos, M., Santolini, M., Ducommun, S., Davaze, R., Guernec, A., Sakamoto, K., and Maire, P. (2016) Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet. Muscle. 6, 30
  2. Sakakibara, I., Santolini, M., Ferry, A., Hakim, V., and Maire, P. (2014) Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet. 10, e1004386
  3. Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T., Hammer, R. E., Kodama, T., Yanagisawa, M., and Sakai, J. (2009) Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 9, 191–202

原著論文

  1. Sakaue, T., Sakakibara, I., Uesugi, T., Fujisaki, A., Nakashiro, K.-I., Hamakawa, H., Kubota, E., Joh, T., Imai, Y.-K., Izutani, H., and Higashiyama, S. (2017) The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. Sci. Rep. 7, 42845
  2. Okamoto, K., Yamasaki, M., Takao, K., Soya, S., Iwasaki, M., Sasaki, K., Magoori, K., Sakakibara, I., Miyakawa, T., Mieda, M., Watanabe, M., Sakai, J., Yanagisawa, M., and Sakurai, T. (2016) QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One. 11, e0164716
  3. Sakakibara, I., Wurmser, M., Dos Santos, M., Santolini, M., Ducommun, S., Davaze, R., Guernec, A., Sakamoto, K., and Maire, P. (2016) Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet. Muscle. 6, 30
  4. Santolini, M., Sakakibara, I., Gauthier, M., Ribas-Aulinas, F., Takahashi, H., Sawasaki, T., Mouly, V., Concordet, J. P., Defossez, P. A., Hakim, V., and Maire, P. (2016) MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis. Nucleic Acids Res. 44, 8621–8640
  5. Lantier, L., Fentz, J., Mounier, R., Leclerc, J., Treebak, J. T., Pehmøller, C., Sanz, N., Sakakibara, I., Saint-Amand, E., Rimbaud, S., Maire, P., Marette, A., Ventura-Clapier, R., Ferry, A., Wojtaszewski, J. F. P., Foretz, M., and Viollet, B. (2014) AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity. FASEB J. 28, 3211–24
  6. Sakakibara, I., Santolini, M., Ferry, A., Hakim, V., and Maire, P. (2014) Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet. 10, e1004386
  7. Silvestre, M. F. P., Viollet, B., Caton, P. W., Leclerc, J., Sakakibara, I., Foretz, M., Holness, M. C., and Sugden, M. C. (2014) The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions. Life Sci. 100, 55–60
  8. Horikawa, D. D., Cumbers, J., Sakakibara, I., Rogoff, D., Leuko, S., Harnoto, R., Arakawa, K., Katayama, T., Kunieda, T., Toyoda, A., Fujiyama, A., and Rothschild, L. J. (2013) Analysis of DNA Repair and Protection in the Tardigrade Ramazzottius varieornatus and Hypsibius dujardini after Exposure to UVC Radiation. PLoS One. 8, e64793
  9. Richard, A.-F., Demignon, J., Sakakibara, I., Pujol, J., Favier, M., Strochlic, L., Le Grand, F., Sgarioto, N., Guernec, A., Schmitt, A., Cagnard, N., Huang, R., Legay, C., Guillet-Deniau, I., and Maire, P. (2011) Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev. Biol. 359, 303–20
  10. Wakabayashi, K., Okamura, M., Tsutsumi, S., Nishikawa, N. S., Tanaka, T., Sakakibara, I., Kitakami, J., Ihara, S., Hashimoto, Y., Hamakubo, T., Kodama, T., Aburatani, H., and Sakai, J. (2009) The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol. Cell. Biol. 29, 3544–55
  11. Okamura, M., Kudo, H., Wakabayashi, K., Tanaka, T., Nonaka, A., Uchida, A., Tsutsumi, S., Sakakibara, I., Naito, M., Osborne, T. F., Hamakubo, T., Ito, S., Aburatani, H., Yanagisawa, M., Kodama, T., and Sakai, J. (2009) COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc. Natl. Acad. Sci. U. S. A. 106, 5819–24
  12. Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T., Hammer, R. E., Kodama, T., Yanagisawa, M., and Sakai, J. (2009) Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 9, 191–202
  13. Ohguchi, H., Tanaka, T., Uchida, A., Magoori, K., Kudo, H., Kim, I., Daigo, K., Sakakibara, I., Okamura, M., Harigae, H., Sasaki, T., Osborne, T. F., Gonzalez, F. J., Hamakubo, T., Kodama, T., and Sakai, J. (2008) Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Mol. Cell. Biol. 28, 3917–31
  14. Sumi, K., Tanaka, T., Uchida, A., Magoori, K., Urashima, Y., Ohashi, R., Ohguchi, H., Okamura, M., Kudo, H., Daigo, K., Maejima, T., Kojima, N., Sakakibara, I., Jiang, S., Hasegawa, G., Kim, I., Osborne, T. F., Naito, M., Gonzalez, F. J., Hamakubo, T., Kodama, T., and Sakai, J. (2007) Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol. Cell. Biol. 27, 4248–60
  15. Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S. C., Iguchi, H., Kawasawa, Y. I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R. X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M., and Sakai, J. (2006) A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc. Natl. Acad. Sci. U. S. A. 103, 7438–43

所属学会

日本分子生物学会、日本筋学会

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