最近の研究成果

2024.03.18: Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
2024.01.02: A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation.
2023.11.27: Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways.
2023.11.15: Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
2023.10.05: RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
2023.10.02: Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
2023.08.21: Chemogenetic activation of G12 signaling enhances adipose tissue browning
2023.07.07: Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity
2023.03.23: Epitranscriptomics in metabolic disease
2022.09.29: MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis
2022.06.24: Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
2022.04.29: Epigenetic and environmental regulation of adipocyte function
2022.03.01: Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis
2021.12.03: Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis
2021.07.26: ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function
2021.07.15: Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals
2021.05.04: Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever
2021.04.30: SETDB1 ユビキチン化の論文がGenes to Cells 誌にアクセプトされました。
2021.04.22: Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.
2020.07.02: 聖マリアンナ医科大学塩野先生らとの研究がScientific Reportsで発表されました
2020.07.01: 米代先生とハーバード大学の梶村先生との共同研究の論文がCell誌に掲載されました。 CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
2020.05.08: Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.
2019.11.30: Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate.
2019.10.11: 東大先端研ニュートリオミクス・腫瘍学分野大澤特任准教授との低栄養に関する研究がCell Report に発表されました。Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2.
2018.11.30: PLoS Genetisオンラインに掲載。熊本大学南敬教授との共同研究。Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.
2018.05.15: JBCに掲載。阪大土井健史教授との共同研究。Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.
2018.04.19: 脂肪を燃えやすくする酵素を特定、Nat Communに掲載。Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.
2018.03.20: Overexpression of p54(nrb)/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.
2017.06.17: Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
2017.06.10: Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
2017.04.03: KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
2017.02.28: Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
2017.01.27: ビタミンＤにSREBPを介した脂質抑制効果の仕組み。　京大上杉教授らとの共同研究
2016.11.11: GPR103欠損マウスは小食で肥満抵抗性。筑波大学櫻井武教授、柳沢正史教授らとの共同研究
2016.10.31: エピゲノム酵素 SETDB1タンパク質のユビキチン化 PLoS Oneオンラインに掲載。阪大土井健史教授との共同研究。
2016.06.28: エピゲノムと免疫に関する論文（小川佳宏教授、菅波教授との共同研究）がScientific reportに掲載されました。
2016.06.02: 脂肪細胞のレビュー、Nature Reviews Molecular Cell Biology
2016.01.05: KDM3A-KLF2-IRF4 axis の発見。-多発性骨髄腫治療への期待 Nature Communications
2015.11.19: 新規なクロマチン構造（H3K9me3/H3K4) ビバレントクロマチン）の発見。脂肪組織中の、前駆脂肪細胞が脂肪細胞にならないようにとどめている仕組みを解明しました。Molecular Cell
2015.09.01: 阪大土井健史教授との共同研究 SETDB1タンパク質の細胞内局在解析
2015.07.06: 新規PPARαモジュレーター(SPPARMα) K-877のマウスとヒト肝臓のトランスクリプトーム解析
2015.05.07: エピゲノム酵素がエピゲノムを修飾する脱メチル化酵素が、寒冷刺激時などに活性化されるメカニズムを解明。阿部さん、ロイハンさんの論文がNature Communicationsに2015年5月7日付オンライン版で発表されました
2015.02.13: 脂肪細胞分化を抑制する新規のポリコーム抑制複合体を解明。
2014.06.02: 田中十志也　准教授の論文　Scientific Reportsにアクセプト田中十志也准教授が研究されてきましたPPARデルタによるCD300aの活性化と炎症性腸疾患のメカニズムについての論文がscientific reportsにアクセプトされました。PPARデルタのchip-seqから標的遺伝子のD300aを同定し、CD300aのノックアウトマウスにおける腸管の免疫過敏性を明らかにした貴重な仕事です。
2014.05.05: スタチンはクロマチン構造変化を介して内皮細胞のKLF4遺伝子を誘導する
2013.08.30: 松村助教の研究がJ.Biol. Chem.lに掲載されました。小胞体のタンパク質の品質管理はHsp/c70とCHIP E3リガーゼ間の協力的な相互作用によって決定される機構の解明
2013.05.01: Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element.
2012.06.06: 低酸素におけるHIF1Aとヒストン脱メチル化酵素Jmjd1aによるクロマチン立体構造変化を介した遺伝子発現制御機構の解明
2012.04.26: 慶応大学医学部　中江淳准教授、伊藤裕教授との共同研究がEMBOジャーナルに掲載されました。Novel repressor regulates insulin sensitivity through interaction with Foxo1.
2011.10.01: 東大病院糖尿病代謝内科　門脇孝教授らとの共同研究がPLos Geneticsに掲載されました。Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation.
2011.08.15: 松村助教の研究がMol Biol Cellに掲載されました。ABC蛋白CFTRの折り畳みと小胞体関連分解におけるHsc70の結合サイクルの重要性の解明。Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.
2011.08.01: Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARalpha-independent mechanisms.
2011.01.01: [Cholesterol feedback: the SREBP pathway].
2010.07.15: Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.
2010.04.01: Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex.
2010.01.01: Role of histone methylation and demethylation in adipogenesis and obesity.
2009.11.20: Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells.
2009.08.28: 脂肪合成を阻害する化合物の作製に成功（京都大学、ベイラー医科大学、東京大学）
2009.08.14: Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
2009.08.01: エピゲノム修飾 -ヒストンH3の９番目のリジンの脱メチル化制御- は肥満・インスリン抵抗性を始めとした生活習慣病の発症に重要である
2009.07.01: 脂肪細胞のマスターレギュレーターPPARγがエピゲノム修飾酵素の遺伝子発現を制御することを介して脂肪細胞への分化を制御する
2009.04.07: Wnt/β-cateninシグナルは、核内受容体COUP-TFIIを介してエピジェネティックにPPARγ遺伝子発現を抑制し、脂肪細胞分化を制御する - Wnt蛋白による脂肪細胞分化の抑制機構の転写シグナルとエピゲノム解析 -
2009.03.01: Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
2009.02.01: 酢酸を活性化する酵素（アセチルCoA合成酵素）欠損マウスは絶食時に体温、持久力が低下する。 ―酢酸が絶食時の燃料になることを発見―
2008.11.26: Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha.
2008.07.01: Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.
2008.06.01: 甲状腺プロホルモン活性化酵素Iodothyronine Deiodinase 1 (Dio1)遺伝子の転写制御機構の解明 − HNF4α、KLF, GATA4はDio1遺伝子プロモーターを相乗的活性化する (Mol. Cell Biol., MCB.02154-02107) −
2007.07.28: [Bile acids and control of lipid metabolism].
2007.06.29: SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.
2007.06.01: New therapeutic target for metabolic syndrome: PPARdelta.
2007.06.01: Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
2007.06.01: Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
2007.06.01: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
2007.01.01: Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
2006.12.28: [PPARalpha, PPARgamma, PPARdelta].
2006.10.01: [SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity].
2006.09.04: Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
2006.06.01: Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome.
2006.05.09: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
2006.04.01: Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.
2006.03.07: Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
2006.01.01: Analysis of PPAR alpha function in human kidney cell line using siRNA.
2005.11.11: SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
2005.10.03: Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.
2005.10.01: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
2005.08.05: Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
2005.08.01: Deficiency of the very low-density lipoprotein (VLDL) receptors in streptozotocin-induced diabetic rats: insulin dependency of the VLDL receptor.
2005.05.01: [Wnt signaling and bone metabolism].
2005.04.01: Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
2004.11.01: [Wnt coreceptor low density lipoprotein receptor related protein 5 (LRP5) mediates the bone formation and glucose induced insulin secretion].
2004.06.01: [Activation of "fat burning sensor" peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome].
2004.06.01: [SREBP controls cholesterol homeostasis].
2004.04.23: A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.
2004.01.01: The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor.
2003.12.23: 核内受容体PPARδの生活習慣病治療薬への適応 - 運動しなくても余分な脂肪を減らす薬－
2003.09.01: Sources of Acetyl-CoA: Acetyl-CoA Synthetase 1 and 2.
2003.06.01: The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues.
2003.03.28: Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.
2003.02.28: Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1.
2003.01.07: Wntシグナルの受容体LRP5を欠損させたマウスでは骨密度の低下とともにインスリン分泌不全による糖代謝異常を引き起こす。－老化における代謝変化を調節するWnt系の役割－
2002.11.01: Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade.
2002.05.10: Remnant lipoprotein particles are taken up into myocardium through VLDL receptor--a possible mechanism for cardiac fatty acid metabolism.
2001.09.21: Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product.
2001.09.07: Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1.
2001.06.01: The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport.
2001.02.27: Evidence of macrophage foam cell formation by very low-density lipoprotein receptor: interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages.
1998.12.18: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.
1998.10.01: SREBP切断酵素 Site-1プロテアーゼ（S1P）の同定
1998.10.01: Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing.
1998.07.10: Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning.
1998.03.06: Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.
1997.12.01: Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
1997.08.08: Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.
1997.05.09: Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.
1996.06.28: 転写因子SREBPの活性化機構を解明
1996.04.26: Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
1996.04.05: Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.
1996.03.01: Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
1995.12.08: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection.
1995.01.17: The role of the very low density lipoprotein receptor in the metabolism of plasma lipoproteins containing ApoE.
1995.01.01: The VLDL receptor and related molecules: Role and function.
1994.03.01: CGG triple repeat polymorphism in VLDL receptor (VLDL-R) gene.
1994.01.21: Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.
1993.07.01: The very low density lipoprotein receptor A second lipoprotein receptor that may mediate uptake of fatty acids into muscle and fat cells.
1992.10.01: Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

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