University of Tokyo, RCAST, Division of Metabolic Medicine

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Significant Publications

  1. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL.
    Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
    EMBO J. 15, 1012-1020, 1996. [PubMed]
  2. Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL.
    Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.
    Cell. 851037-851046, 1996. [DOI] [PubMed]
  3. Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL.
    Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
    Mol Cell. 147-57, 1997. [DOI] [PubMed]
  4. Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS.
    Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.
    Mol Cell. 1998 Oct;2(4):505-14. [DOI] [PubMed]
  5. Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J*(* corresponding author), Yamamoto TT*.
    Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion.
    Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34. Epub 2002 Dec 30. [DOI] [PubMed]
  6. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J* (* corresponding authors).
    Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
    Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9. Epub 2003 Dec 15. [DOI] [PubMed]
  7. Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J*(* corresponding author).
    A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
    Proc Natl Acad Sci U S A. 2006 May 9;103(19):7438-43. Epub 2006 Apr 28. [DOI] [PubMed]
  8. Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, Maejima T, Kojima N, Sakakibara I, Jiang S, Hasegawa G, Kim I, Osborne TF, Naito M, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J*(* corresponding author).
    Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
    Mol Cell Biol. 27, 4248-4260, 2007. [DOI] [PubMed]
  9. Ohguchi H, Tanaka T, Uchida A, Magoori K, Kudo H, Kim I, Daigo K, Sakakibara I, Okamura M, Harigae H, Sasaki T, Osborne TF, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J*(* corresponding author).
    Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.
    Mol Cell Biol. 28, 3917-3931, 2008. [DOI] [PubMed]
  10. Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J*(* corresponding author).
    Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
    Cell Metab. 9, 191-202, 2009. [DOI] [PubMed]
  11. Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J*(* corresponding author).
    COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
    Proc Natl Acad Sci U S A. 106, 5819-5824, 2009. [DOI] [PubMed]
  12. Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J*(* corresponding author).
    The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.
    Mol Cell Biol. 29, 3544-3555, 2009. [DOI] [PubMed]
  13. Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J*(* corresponding author).
    Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
    Genes Cells. 14, 991-1001, 2009. [DOI] [PubMed]
  14. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M.
    A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
    Chem Biol. 16, 882-892, 2009. [DOI] [PubMed]
  15. Abe Y1, Rozqie R1, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki* T, Sakai* J. (1 equal contribution, * corresponding authors)
    JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis
    Nature Comm. 6, 7052, 2015. [DOI] [PubMed]
  16. Matsumura Y*, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J* (* corresponding authors)
    H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-specific DNA Methylation Pauses Adipocyte Differentiation
    Mol Cell. 60, 584-596, 2015. [DOI] [PubMed]
  17. Ohguchi H, Hideshima T, Bhasin MK, Gorgun GT, Santo L, Cea M, Mimura N, Suzuki R, Tai Y-T, Carrasco RD, Raje N, Richardson PG, Harigae H, Sanda T, Sakai J, Anderson KC
    The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.
    Nature Commun. 2016, 7, 10258. [DOI] [PubMed]
  18. Inagaki T,Sakai J, Kajimura S
    Transcriptional and epigenetic control of Brown/Beige adipocyte development
    Nature Reviews Molecular Cell Biology. 7, 480-495, 2016. [DOI] [PubMed]
  19. Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M
    Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP
    Cell Chemical Biology 24, 207-217, 2017. [DOI] [PubMed] [Journal Web Site]
  20. Abe Y, Fujiwara Y, Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, Inagaki T, Sakai J* (* corresponding authors).
    Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.
    Nat Commun. 9, 1566, 2018. [DOI] [PubMed] [Journal Web Site]

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