University of Tokyo, RCAST, Division of Metabolic Medicine

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Publications

  1. Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T, Kodama T.
    Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2.
    Cell Rep. 2019 Oct 1;29 :89-103.e7. [DOI] [PubMed] [Journal Web Site]
  2. Nagai N, Ohguchi H, Nakaki R, Matsumura Y, Kanki Y, Sakai J, Aburatani H, Minami T.
    Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.
    PLoS Genet. 14, e1007826, 2018. [DOI] [PubMed] [Journal Web Site]
  3. Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T.
    Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.
    J Biol Chem. 293, 10333-10343, 2018. [DOI] [PubMed] [Journal Web Site]
  4. Abe Y, Fujiwara Y, Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, Inagaki T, Sakai J* (* corresponding authors).
    Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.
    Nat Commun. 9, 1566, 2018. [DOI] [PubMed] [Journal Web Site]
  5. Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T.
    Overexpression of p54(nrb)/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.
    Oncotarget. 9, 10510-10524, 2018. [DOI] [PubMed] [Journal Web Site]
  6. Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T.
    Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
    Biochem Biophys Res Commun. 488, 159-164, 2017. [DOI] [PubMed] [Journal Web Site]
  7. Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K.
    Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
    Oncogene. 36, 6262-6271, 2017. [PubMed] [Journal Web Site]
  8. Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, Mill P.
    KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
    J Cell Biol. 216, 999-1013, 2017. [PubMed] [Journal Web Site]
  9. Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H, Osawa T.
    Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
    Cell Rep. 18, 2228-2242, 2017. [PubMed] [Journal Web Site]
  10. Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M
    Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP
    Cell Chemical Biology 24, 207-217, 2017. [DOI] [PubMed] [Journal Web Site]
  11. Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T.
    QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.
    PLoS One 11, e0164716, 2016. [DOI] [PubMed]
  12. Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T
    Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity
    PLoS One 11, e0165766, 2016. [DOI] [PubMed]
  13. Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T, Ogawa Y.
    The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.
    Sci Rep. 6, 28845, 2016. [DOI] [PubMed]
  14. Inagaki T,Sakai J, Kajimura S
    Transcriptional and epigenetic control of Brown/Beige adipocyte development
    Nature Reviews Molecular Cell Biology. 7, 480-495, 2016. [DOI] [PubMed]
  15. Ohguchi H, Hideshima T, Bhasin MK, Gorgun GT, Santo L, Cea M, Mimura N, Suzuki R, Tai Y-T, Carrasco RD, Raje N, Richardson PG, Harigae H, Sanda T, Sakai J, Anderson KC
    The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.
    Nature Commun. 2016, 7, 10258. [DOI] [PubMed]
  16. Matsumura Y*, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J* (* corresponding authors)
    H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-specific DNA Methylation Pauses Adipocyte Differentiation
    Mol Cell. 60, 584-596, 2015. [DOI] [PubMed]
  17. Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.
    Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
    Biochem Biophys Res Commun. 465, 725-731, 2015. [DOI] [PubMed]
  18. Raza-Iqbal S, Tanaka T, Anai M, Inagaki T, Matsumura Y, Ikeda K, Taguchi A, Gonzalez FJ, Sakai J, Kodama T.
    Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
    J Atheroscler Thromb. 22, 754-772, 2015. [DOI] [PubMed]
  19. Abe Y1, Rozqie R1, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki* T, Sakai* J. (1 equal contribution, * corresponding authors)
    JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis
    Nature Comm. 6, 7052, 2015. [DOI] [PubMed]
  20. Inagaki T1,2, Iwasaki S1, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J2 (1 equal contribution, 2 corresponding authors)
    The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis
    J Biol Chem. 290, 4163-4177, 2015. [DOI] [PubMed]
  21. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Johan A, J. GF, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J* (* corresponding authors)
    PPAR beta/delta activation of CD300a controls intestinal immunity.
    Scientific Reports. 4, 5412, 2014. [DOI] [PubMed]
  22. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y.
    Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells
    PLoS One. 9, e96005, 2014. [DOI] [PubMed]
  23. Matsumura Y, Sakai J, Skach WR.
    Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 and the CHIP E3 ligase
    J Biol Chem. 288, 31069-31079, 2013. [DOI] [PubMed]
  24. Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T.
    Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element.
    J Biochem. 154, 265-273, 2013. [DOI] [PubMed]
  25. Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro JI, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y.
    Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A.
    Mol Cell Biol. 32, 3018-3032, 2012. [DOI] [PubMed]
  26. Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi SI, Itoh H.
    Novel repressor regulates insulin sensitivity through interaction with Foxo1.
    EMBO J. 31, 2275-2295, 2012. [DOI] [PubMed]
  27. Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J*(* corresponding author), Aburatani H*, Kadowaki T*.
    Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation.
    PLoS Genet. 7, e1002311, 2011. [DOI] [PubMed]
  28. Matsumura Y, David LL, Skach WR.
    Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.
    Mol Biol Cell. 2011 Aug 15;22(16):2797-809. Epub 2011 Jun 22. [DOI] [PubMed]
  29. Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T.
    Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARalpha-independent mechanisms.
    Eur J Cell Biol. 90, 657-664, 2011. [DOI] [PubMed]
  30. Sakai J.
    [Cholesterol feedback: the SREBP pathway].
    Nihon Rinsho. 69, 241-258, 2011. [PubMed]
  31. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.
    Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.
    Biochem J. 429347-357, 2010. [DOI] [PubMed]
  32. Kuwahara A, Hirabayashi Y, Knoepfler PS, Taketo MM, Sakai J, Kodama T, Gotoh Y.
    Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex.
    Development. 137, 1035-1044, 2010. [DOI] [PubMed]
  33. Okamura M, Inagaki T, Tanaka T, Sakai J*(* corresponding author).
    Role of histone methylation and demethylation in adipogenesis and obesity.
    Organogenesis. 6, 24-32, 2010. [PubMed]
  34. Tachibana K, Takeuchi K, Inada H, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.
    Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells.
    Biochem Biophys Res Commun. 389, 501-505, 2009. [DOI] [PubMed]
  35. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M.
    A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
    Chem Biol. 16, 882-892, 2009. [DOI] [PubMed]
  36. Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.
    Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
    J Biol Chem. 284, 22195-22205, 2009. [DOI] [PubMed]
  37. Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J*(* corresponding author).
    Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
    Genes Cells. 14, 991-1001, 2009. [DOI] [PubMed]
  38. Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J*(* corresponding author).
    The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.
    Mol Cell Biol. 29, 3544-3555, 2009. [DOI] [PubMed]
  39. Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J*(* corresponding author).
    COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
    Proc Natl Acad Sci U S A. 106, 5819-5824, 2009. [DOI] [PubMed]
  40. Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M.
    Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
    Pathol Int. 59, 152-160, 2009. [DOI] [PubMed]
  41. Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J*(* corresponding author).
    Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
    Cell Metab. 9, 191-202, 2009. [DOI] [PubMed]
  42. Tachibana K, Anzai N, Ueda C, Katayama T, Yamasaki D, Kirino T, Takahashi R, Ishimoto K, Komori H, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T.
    Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha.
    FEBS Lett. 582, 3884-3888, 2008. [DOI] [PubMed]
  43. Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA.
    Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.
    Cell Metab. 2008 Jul;8(1):77-83. [DOI] [PubMed]
  44. Ohguchi H, Tanaka T, Uchida A, Magoori K, Kudo H, Kim I, Daigo K, Sakakibara I, Okamura M, Harigae H, Sasaki T, Osborne TF, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J*(* corresponding author).
    Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.
    Mol Cell Biol. 28, 3917-3931, 2008. [DOI] [PubMed]
  45. Tanaka T, Sakai J, Kodama T.
    [Bile acids and control of lipid metabolism].
    Nihon Rinsho. 65 Suppl 7, 557-563, 2007. [PubMed]
  46. Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J*(* corresponding author).
    SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.
    J Biol Chem. 282, 19052-19061, 2007. [DOI] [PubMed]
  47. Takahashi S, Tanaka T, Sakai J.
    New therapeutic target for metabolic syndrome: PPARdelta.
    Endocr J. 2007 Jun;54(3):347-57. Epub 2007 Apr 3. [PubMed]
  48. Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, Maejima T, Kojima N, Sakakibara I, Jiang S, Hasegawa G, Kim I, Osborne TF, Naito M, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J*(* corresponding author).
    Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
    Mol Cell Biol. 27, 4248-4260, 2007. [DOI] [PubMed]
  49. Sakamoto A, Kawasaki T, Kazawa T, Ohashi R, Jiang S, Maejima T, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M.
    Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
    J Histochem Cytochem. 55, 641-649, 2007. [DOI] [PubMed]
  50. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.
    Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
    Cell Metab. 5, 415-425, 2007. [DOI] [PubMed]
  51. Tachibana K, Katayama T, Ueda C, Sumitomo M, Tagami M, Ishimoto K, Yamasaki D, Tanaka T, Hamakubo T, Sakai J, Kodama T, Obika S, Imanishi T, Doi T.
    Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
    Nucleic Acids Symp Ser (Oxf). (51), 441-442, 2007. [DOI] [PubMed]
  52. Takahashi S, Sakai J.
    [PPARalpha, PPARgamma, PPARdelta].
    Nihon Rinsho. 64 Suppl 9, 259-262, 2006. [PubMed]
  53. Iguchi H, Sakai J.
    [SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity].
    Nihon Yakurigaku Zasshi. 2006 Oct;128(4):219-24. [PubMed]
  54. Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.
    Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
    FEBS Lett. 2006 Sep 4;580(20):4929-33. Epub 2006 Aug 14. [DOI] [PubMed]
  55. Takahashi S, Tanaka T, Kodama T, Sakai J.
    Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome.
    Pharmacol Res. 2006 Jun;53(6):501-7. Epub 2006 Mar 29. [DOI] [PubMed]
  56. Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J*(* corresponding author).
    A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
    Proc Natl Acad Sci U S A. 2006 May 9;103(19):7438-43. Epub 2006 Apr 28. [DOI] [PubMed]
  57. Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M, Kodama T.
    Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.
    J Pathol. 2006 Apr;208(5):662-72. [DOI] [PubMed]
  58. Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, Downes M, Yu RT, Shelton JM, Richardson JA, Repa JJ, Mangelsdorf DJ, Kliewer SA.
    Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
    Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3920-5. Epub 2006 Feb 10. [DOI] [PubMed]
  59. Tachibana K, Anzai N, Ueda C, Katayama T, Kirino T, Takahashi R, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T.
    Analysis of PPAR alpha function in human kidney cell line using siRNA.
    Nucleic Acids Symp Ser (Oxf). 2006;(50):257-8. [DOI] [PubMed]
  60. Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J*(* corresponding author).
    SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
    J Biol Chem. 2005 Nov 11;280(45):37669-80. Epub 2005 Sep 7. [DOI] [PubMed]
  61. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T.
    Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.
    Nucl Recept. 2005 Oct 3;3:3. Epub 2005 Oct 3. [DOI] [PubMed]
  62. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA.
    Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
    Cell Metab. 2005 Oct;2(4):217-25. [DOI] [PubMed]
  63. Ikeda Y, Iguchi H, Nakata M, Ioka RX, Tanaka T, Iwasaki S, Magoori K, Takayasu S, Yamamoto TT, Kodama T, Yada T, Sakurai T, Yanagisawa M, Sakai J* (* corresponding authors).
    Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
    Biochem Biophys Res Commun. 2005 Aug 5;333(3):778-86. [DOI] [PubMed]
  64. Iwasaki T, Takahashi S, Takahashi M, Zenimaru Y, Kujiraoka T, Ishihara M, Nagano M, Suzuki J, Miyamori I, Naiki H, Sakai J, Fujino T, Miller NE, Yamamoto TT, Hattori H.
    Deficiency of the very low-density lipoprotein (VLDL) receptors in streptozotocin-induced diabetic rats: insulin dependency of the VLDL receptor.
    Endocrinology. 2005 Aug;146(8):3286-94. Epub 2005 May 5. [DOI] [PubMed]
  65. Asaba H, Sakai J.
    [Wnt signaling and bone metabolism].
    Clin Calcium. 2005 May;15(5):813-8. [PubMed]
  66. Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T.
    Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
    Nat Med. 2005 Apr;11(4):400-8. Epub 2005 Mar 20. [DOI] [PubMed]
  67. Sakai J.
    [Wnt coreceptor low density lipoprotein receptor related protein 5 (LRP5) mediates the bone formation and glucose induced insulin secretion].
    Nihon Ronen Igakkai Zasshi. 2004 Nov;41(6):625-8. [PubMed]
  68. Sakai J.
    [Activation of "fat burning sensor" peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome].
    Seikagaku. 2004 Jun;76(6):517-24. [PubMed]
  69. Sato R, Sakai J.
    [SREBP controls cholesterol homeostasis].
    Seikagaku. 76, 503-508, 2004. [PubMed]
  70. Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, Asaba H, Iwasaki S, Ioka RX, Kaneko IW, Magoori K, Takahashi S, Mori T, Sakaue H, Kodama T, Yanagisawa M, Yamamoto TT, Ito S, Sakai J* (* corresponding authors).
    A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.
    J Biol Chem. 2004 Apr 23;279(17):16954-62. Epub 2004 Feb 10. [DOI] [PubMed]
  71. Takahashi S, Sakai J, Fujino T, Hattori H, Zenimaru Y, Suzuki J, Miyamori I, Yamamoto TT.
    The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor.
    J Atheroscler Thromb. 2004;11(4):200-8. [PubMed]
  72. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J* (* corresponding authors).
    Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
    Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9. Epub 2003 Dec 15. [DOI] [PubMed]
  73. Fujino T, Ikeda Y, Osborne TF, Takahashi S, Yamamoto TT, Sakai J.
    Sources of Acetyl-CoA: Acetyl-CoA Synthetase 1 and 2.
    Curr Med Chem. 2003;3(3):207-210. [DOI]
  74. Takahashi S, Sakai J, Fujino T, Miyamori I, Yamamoto TT.
    The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues.
    Mol Cell Biochem. 2003 Jun;248(1-2):121-7. [PubMed]
  75. Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT.
    Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.
    J Biol Chem. 2003 Mar 28;278(13):11331-6. Epub 2002 Dec 31. [DOI] [PubMed]
  76. Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT.
    Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1.
    J Biol Chem. 2003 Feb 28;278(9):7344-9. Epub 2002 Dec 20. [DOI] [PubMed]
  77. Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J*(* corresponding author), Yamamoto TT*.
    Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion.
    Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34. Epub 2002 Dec 30. [DOI] [PubMed]
  78. Gong JS, Sawamura N, Zou K, Sakai J, Yanagisawa K, Michikawa M.
    Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade.
    J Neurosci Res. 2002 Nov 1;70(3):438-46. [DOI] [PubMed]
  79. Kamataki A, Takahashi S, Masamura K, Iwasaki T, Hattori H, Naiki H, Yamada K, Suzuki J, Miyamori I, Sakai J, Fujino T, Yamamoto TT.
    Remnant lipoprotein particles are taken up into myocardium through VLDL receptor--a possible mechanism for cardiac fatty acid metabolism.
    Biochem Biophys Res Commun. 2002 May 10;293(3):1007-13. [DOI] [PubMed]
  80. Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT.
    Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product.
    J Biol Chem. 2001 Sep 21;276(38):35961-6. Epub 2001 Jul 24. [DOI] [PubMed]
  81. Ikeda Y, Yamamoto J, Okamura M, Fujino T, Takahashi S, Takeuchi K, Osborne TF, Yamamoto TT, Ito S, Sakai J* (* corresponding authors).
    Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1.
    J Biol Chem. 2001 Sep 7;276(36):34259-69. Epub 2001 Jul 2. [DOI] [PubMed]
  82. Sakai J, Rawson RB.
    The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport.
    Curr Opin Lipidol. 2001 Jun;12(3):261-6. Review. [PubMed]
  83. Kosaka S, Takahashi S, Masamura K, Kanehara H, Sakai J, Tohda G, Okada E, Oida K, Iwasaki T, Hattori H, Kodama T, Yamamoto T, Miyamori I.
    Evidence of macrophage foam cell formation by very low-density lipoprotein receptor: interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages.
    Circulation. 2001 Feb 27;103(8):1142-7. [DOI] [PubMed]
  84. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW.
    cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.
    J Biol Chem. 273, 34316-34327, 1998. [DOI] [PubMed]
  85. Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS.
    Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.
    Mol Cell. 1998 Oct;2(4):505-14. [DOI] [PubMed]
  86. Iijima H, Miyazawa M, Sakai J, Magoori K, Ito MR, Suzuki H, Nose M, Kawarabayasi Y, Yamamoto TT.
    Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing.
    J Biochem. 124, 747-55, 1998. [PubMed]
  87. Duncan EA, Davé UP, Sakai J, Goldstein JL, Brown MS.
    Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning.
    J Biol Chem. 273, 17801-17809, 1998. [DOI] [PubMed]
  88. Sakai J, Nohturfft A, Goldstein JL, Brown MS.
    Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.
    J Biol Chem. 273, 5785-5793, 1998. [DOI] [PubMed]
  89. Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL.
    Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
    Mol Cell. 147-57, 1997. [DOI] [PubMed]
  90. Sakai J, Nohturfft A, Cheng D, Ho YK, Brown MS, Goldstein JL.
    Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.
    J Biol Chem. 272, 20213-20221, 1997. [DOI] [PubMed]
  91. Duncan EA, Brown MS, Goldstein JL, Sakai J.
    Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.
    J Biol Chem. 272, 12778-12785, 1997. [DOI] [PubMed]
  92. Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL.
    Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.
    Cell. 851037-851046, 1996. [DOI] [PubMed]
  93. Hua X, Sakai J, Brown MS, Goldstein JL.
    Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
    J Biol Chem. 271, 10379-10384, 1996. [DOI] [PubMed]
  94. Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T.
    Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.
    J Biol Chem. 271, 8373-8380, 1996. [DOI] [PubMed]
  95. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL.
    Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
    EMBO J. 15, 1012-1020, 1996. [PubMed]
  96. Hua X, Sakai J, Ho YK, Goldstein JL, Brown MS.
    Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection.
    J Biol Chem. 270, 29422-29427, 1995. [DOI] [PubMed]
  97. Yamamoto T, Hoshino A, Takahashi S, Kawarabayasi Y, Iijima H, Sakai J.
    The role of the very low density lipoprotein receptor in the metabolism of plasma lipoproteins containing ApoE.
    Ann N Y Acad Sci. 748, 217-24, 1995. [DOI] [PubMed]
  98. Yamamoto T, Sakai J.
    The VLDL receptor and related molecules: Role and function.
    Atherosclerosis . X, 457-460, 1995.
  99. Jokinen E, Sakai J, Yamamoto T, Hobbs HH.
    CGG triple repeat polymorphism in VLDL receptor (VLDL-R) gene.
    Hum Mol Genet. 3, 521, 1994. [DOI] [PubMed]
  100. Sakai J, Hoshino A, Takahashi S, Miura Y, Ishii H, Suzuki H, Kawarabayasi Y, Yamamoto T.
    Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.
    J Biol Chem. 269, 2173-2182, 1994. [PubMed]
  101. Yamamoto T, Takahashi S, Sakai J, Kawarabayasi Y.
    The very low density lipoprotein receptor A second lipoprotein receptor that may mediate uptake of fatty acids into muscle and fat cells.
    Trends Cardiovasc Med. 3, 144-8,1993. [DOI] [PubMed]
  102. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T.
    Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.
    Proc Natl Acad Sci U S A. 89, 9252-9256, 1992. [PubMed]

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