東京大学先端科学技術研究センター 代謝医学分野 酒井研究室

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客員上級研究員(東北大学大学院准教授) 松村 欣宏(まつむら よしひろ)

松村欣宏

略歴

1998年3月 東北大学工学部生物化学工学科卒業
2001年3月 東北大学理学研究科化学専攻 博士前期課程修了
2004年3月 東北大学理学研究科化学専攻 博士後期課程修了(理学博士)
2004年6月 秋田大学医学部生理学第一講座 研究員
2008年1月 米国オレゴンヘルスサイエンス大学 生化学・分子生物学部門 研究員
2011年9月 東京大学特任助教(先端科学技術研究センター代謝医学分野)
2012年4月 東京大学助教(先端科学技術研究センター代謝医学分野)
2017年4月 東京大学准教授(先端科学技術研究センター代謝医学分野)
2022年4月 東北大学准教授(大学院医学系研究科分子代謝生理学分野)現在に至る

代表論文

  1. Matsumura Y*, Ito R*, Yajima Y*, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue S, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nat Commun  (2021) 12, 7045.                  PMID: 34857762
  2. Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J. H3K4/H3K9me3 bivalent chromatin domains targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Mol Cell (2015) 60, 584-596.
    PMID: 26590716
  3. PMID: 23990462
  4.  Matsumura Y, Ban N, Ueda K, Inagaki N. Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiencyJ Biol Chem (2006) 281, 34503-34514.
    PMID: 16959783

原著論文

  1. Pan M, Zorbas C, Sugaya M, Ishiguro K, Kato M, Nishida M, Zhang HF, Candeias MM, Okamoto A, Ishikawa T, Soga T, Aburatani H, Sakai J, Matsumura Y, Suzuki T, Proud CG, Lafontaine DLJ, Osawa T. Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors. Nat Commun (2022) 13, 3706.
  2. Murakami K, Sasaki Y, Asahiyama M, Yano W, Takizawa T, Kamiya W, Matsumura Y, Anai M, Osawa T, Fruchart JC, Fruchart-Najib J, Aburatani H, Sakai J, Kodama T, Tanaka T. Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis. Cells (2022) 11.
  3. Matsumura Y, Osborne TF, Sakai J. Epigenetic and environmental regulation of adipocyte function. J Biochem (2022) 172, 9-16.
  4. Matsumura Y*, Ito R*, Yajima Y*, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue S, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nat Commun (2021) 12, 7045.
  5. Zhang J, Matsumura Y, Kano Y, Yoshida A, Kawamura T, Hirakawa H, Inagaki T, Tanaka T, Kimura H, Yanagi S, Fukami K, Doi T, Osborne TF, Kodama T, Aburatani H, Sakai J. Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis. Genes Cells (2021) 26, 513-529.
  6. Matsumura Y*, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J* (*corresponding authors) 
    H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-specific DNA Methylation Pauses Adipocyte Differentiation. Mol Cell (2015) 60, 584-596.
  7. Matsumura Y, Sakai J, Skach WR. Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem (2013) 288, 31069-31079.
  8. Devaraneni PK, Conti B, Matsumura Y, Yang Z, Johnson AE, Skach WR. Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex. Cell (2011) 146, 134-147.
  9. Matsumura Y, David LL, Skach WR. Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell (2011) 22, 2797-2809.
  10. Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2010) 6, 25-33.
  11. Park SK, Amos L, Rao A, Quasney MW, Matsumura Y, Inagaki N, Dahmer MK. Identification and characterization of a novel ABCA3 mutation. Physiol Genomics (2010) 40, 94-99.
  12. Pitonzo D, Yang Z, Matsumura Y, Johnson AE, Skach WR. Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon. Mol Biol Cell (2009) 20, 685-698.
  13. Matsumura Y, Ban N, Inagaki N. Aberrant catalytic cycle and impaired lipid transport into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung disease. Am J Physiol Lung Cell Mol Physiol (2008) 295, L698-L707.
  14. Kodaira Y, Kusumoto T, Takahashi T, Matsumura Y Miyagi Y, Okamoto K, Shidoji Y, Sagami H. Formation of lipid droplets induced by 2,3-dihydrogeranylgeranoic acid distinct from geranylgeranoic acid. Acta Biochim Pol (2007) 54, 777-782.
  15. Matsumura Y, Kidokoro T, Miyagi Y, Marilingaiah NR, Sagami H. The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. J Biochem (2007) 142, 533-537.
  16. Miyagi Y, Matsumura Y, Sagami H. Human geranylgeranyl diphosphate synthase is an octamer in solution. J Biochem (2007) 142, 377-381.
  17. *Yokota T, *Matsumura Y, Ban N, Matsubayashi T, Inagaki N. (*Equally contributed.) Heterozygous ABCA3 mutation associated with non-fatal evolution of respiratory distress. Eur J Pediatr (2008) 167, 691-693.
  18. Matsumura Y, Sakai H, Sasaki M, Ban N, Inagaki N. ABCA3-mediated choline-phospholipids uptake into intracellular vesicles in A549 cells. FEBS Lett. (2007) 581, 3139-3144.
  19. Sakai H, Tanaka Y, Tanaka M, Ban N, Yamada K, Matsumura Y, Watanabe D, Sasaki M, Kita T, Inagaki N. ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J Biol Chem (2007) 282, 19692-19699.
  20. Ban N, Matsumura Y, Sakai H, Takanezawa Y, Sasaki M, Arai H, Inagaki N. ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J Biol Chem (2007) 282, 9628-9634.
  21. Matsumura Y, Ban N, Ueda K, Inagaki N. Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency. J Biol Chem (2006) 281, 34503-34514.
  22. Matsumura Y, Kuzuguchi T, Sagami H. Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level. J Biochem (2004) 136, 301-312.
  23. Szabo CM, Matsumura Y, Fukura S, Martin MB, Sanders JM, Sengupta S, Cieslak JA, Loftus TC, Lea CR, Lee HJ, Koohang A, Coates RM, Sagami H, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem (2002) 45, 2185-2196.

 

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日本分子生物学会

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