准教授 米代 武司(よねしろ たけし)
略歴
2007年3月 | 天使大学看護栄養学部 卒業 |
2010年3月 | 天使大学 看護栄養学研究科 博士前期課程 修了 |
2013年3月 | 北海道大学 医学研究科 博士課程 修了(博士(医学)) |
2012年4月 | 北海道大学 医学研究科 研究員(学振特別研究員) |
2014年4月 | 北海道大学 獣医学研究科 研究員(学振特別研究員) |
2016年7月 | 米国カリフォルニア大学サンフランシスコ校 糖尿病センター 研究員 (学振特別研究員・同海外特別研究員) |
2020年4月 | 東京大学 先端科学技術研究センター 代謝医学分野 特任助教 |
2021年2月 | 東京大学 先端科学技術研究センター 代謝医学分野 助教 |
2022年4月 | 東京大学 先端科学技術研究センター 代謝医学分野 准教授 現在に至る |
代表論文
- Yoneshiro T*, Wang Q*, Tajima K, Matsushita M, Maki H, Igarashi K, Dai J, White PJ, McGarrah RQ, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature 572: 614–619, 2019 *Equal contribution
- Yoneshiro T#, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M. Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest 123: 3404-3408, 2013 #Corresponding author
原著論文
- Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature, 2022
- Izawa S, Yoneshiro T, Kondoh K, Nakagiri S, Okamatsu-Ogura Y, Terao A, Minokoshi Y, Yamanaka A, Kimura K. Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure. J Physiol 600: 815-827, 2022
- Yoshida N, Yamashita T, Osone T, Hosooka T, Shinohara M, Kitahama S, Sasaki K, Sasaki D, Yoneshiro T, Suzuki T, Emoto T, Saito Y, Ozawa G, Hirota Y, Kitaura Y, Shimomura Y, Okamatsu-Ogura Y, Saito M, Kondo A, Kajimura S, Inagaki T, Ogawa W, Yamada T, Hirata KI. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience 24: 103342, 2021
- Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Elife 10: e66865, 2021
- Walejko JM, Christopher BA, Crown SB, Zhang GF, Pickar-Oliver A, Yoneshiro T, Foster MW, Page S, van Vliet S, Ilkayeva O, Muehlbauer MJ, Carson MW, Brozinick JT, Hammond CD, Gimeno RE, Moseley MA, Kajimura S, Gersbach CA, Newgard CB, White PJ, McGarrah RW. Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart. Nat Commun 12: 1680, 2021
- Nabatame Y, Hosooka T, Aoki C, Hosokawa Y, Imamori M, Tamori Y, Okamatsu-Ogura Y, Yoneshiro T, Kajimura S, Saito M, Ogawa W. Kruppel-like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes. J Diabetes Investig 12: 1144-1151, 2021
- Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nat Commun 12: 7045, 2021
- Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S. The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication. EMBO Rep 21: e49828, 2020
- Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell 182: 563-577.e520, 2020
- Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. Wireless optogenetics protects against obesity via stimulating non-canonical fat thermogenesis. Nat Commun 11: 1730, 2020
- Yoneshiro T*, Wang Q*, Tajima K, Matsushita M, Maki H, Igarashi K, Dai J, White PJ, McGarrah RQ, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature 572: 614–619, 2019 *Equal contribution
- Yoneshiro T*, #, Shin W*, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura K. Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation. FASEB J 33: 5196-5207, 2019 *Equal contribution, #Corresponding author
- Yoneshiro T#, Matsushita M, Saito M. Translational aspects of brown fat activation by food-derived stimulants. Handb Exp Pharmacol 251: 359-379, 2019 #Corresponding author
- Chen Y, Ikeda K, Yoneshiro T*, Scaramozza A*, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature 565: 180-185, 2019 (IF=43.070) *Equal contribution
- Tajima K, Ikeda K, Chang HY, Chang CH, Yoneshiro T, Oguri Y, Jun H, Wu J, Ishihama Y, Kajimura S. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nat Metab 1: 886–898, 2019
- Yoneshiro T, Kaede R, Nagaya K, Saito M, Aoyama J, Elfeky M, Okamatsu-Ogura Y, Kimura K, Terao A. Melinjo (Gnetum gnemon L.) seed extract stimulates brown fat thermogenesis and protects mice against obesity, inflammation, and insulin resistance. Nutr Res 58: 17-25, 2018
- Yoneshiro T, Kaede R, Nagaya K, Aoyama J, Saito M, Izawa S, Okamatsu-Ogura Y, Kimura K, Terao A. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obes Res Clin Pract 12: 127-137, 2018
- Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of systemic succinate controls activation of adipose tissue thermogenesis. Nature 560: 102-106, 2018
- Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K. Suppression by adiponectin of late inflammatory mediator, HMGB1-induced cytokine expression in RAW 264 macrophage cells. J Biochem 163: 143-153, 2018
- Fuse S, Nirengi S, Amagasa S, Homma T, Kime R, Endo T, Sakane N, Saito M, Yoneshiro T, Kurosawa Y, Hamaoka T. Brown adipose tissue density and seasonal lower outdoor temperature in Japanese men and women with a wide range of age. J Biomed Opt 23: 1-9, 2018
- Lu X, Altshuler-Keylin S, Wang Q, Chen Y, Sponton CH, Ikeda K, Maretich P, Yoneshiro T, Kajimura S. Mitophagy controls beige adipocyte maintenance through a UCP1-independent mechanism. Sci Signal 11: 527, 2018
- Yoneshiro T#, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Katsuragi Y, Kameya T, Sugie H, Saito M. Tea catechin activates and recruits brown adipose tissue in humans. Am J Clin Nutr 105: 873-881, 2017 #Corresponding author
- Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P, Tajima K, Ajuwon KM, Soga T, Kajimura S. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med 23: 1454-1465, 2017
- Uchida K*, Dezaki K*, Yoneshiro T*, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki I. Involvement of thermo-TRP channels in energy metabolism. J Physiol Sci 67: 549-560, 2017 *Equal contribution
- Yoneshiro T#, Matsushita M, Nakae S, Kameya T, Sugie H, Tanaka S, Saito M. Brown adipose tissue determines seasonal changes in thermoregulatory responses to cold exposure in humans. Am J Physiol Regul Integr Comp Physiol 310: R999-R1009, 2016 #Corresponding author
- Saito M, Yoneshiro T, Matsushita M. Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans. Best Pract Res Clin Endoc Metab, 30: 537-547, 2016
- Nirengi S, Homma T, Inoue N, Sato H, Yoneshiro T, Tsuzaki K, Saito M, Sakane N, Kurosawa Y, Hamaoka T. Near-infrared time resolved spectroscopy assessment of changes in human brown adipose tissue density during repeated capsiate intake and intake cessation. J Biomed Opt 21: 091305, 2016
- Nirengi S, Yoneshiro T, Saiki T, Aita S, Matsushita M, Sugie H, Saito M, Hamaoka T. Evaluation of brown adipose tissue using near-infrared time-resolved spectroscopy. Adv Exp Med Biol 876: 371-376, 2016
- Nirengi S, Amagasa S, Homma T, Yoneshiro T, Matsumiya S, Kurosawa Y, Sakane N, Ebi K, Saito M, Hamaoka T. Catechin-rich beverage intake for 12 weeks increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women: a randomized controlled trial. SpringerPlus 5: 1363, 2016
- Hibi M, Oishi S, Matsushita M, Yoneshiro T, Yamaguchi T, Usui C, Yasunaga K, Kubota K, Tanaka S, Saito M. Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans. Int J Obesity 40:1655-1661, 2016
- Yoneshiro T, Saito M. Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. Ann Med 47: 133-141, 2015
- Saito M, Yoneshiro T, Matsushita M. Food ingredients as anti-obesity agents. Trends Endocrinol Metab 26: 585-587, 2015
- Nirengi S, Yoneshiro T, Sugie H, Saito M, Hamaoka T. A novel simple method for detecting brown adipose tissue using near-infrared time-resolved spectroscopy. Obesity (Silver Spring) 23: 973-980, 2015
- Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi K, Takagaki K, Kameya T, Sugie H, Saito M. Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. J Nutr Sci Vitaminol 61: 79-83, 2015
- Matsushita M, Yoneshiro T, Aita S, Kameya T, Sugie H, Saito M. Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans. Int J Obesity 38: 812-817, 2014
- Sugita J, Yoneshiro T, Sugishima Y, Ikemoto T, Uchiwa H, Iwanaga T, Suzuki I, Saito M. Daily ingestion of Grains of Paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J Nutr Sci Vitaminol 60: 22-27, 2014
- Yoneshiro T#, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M. Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest 123: 3404-3408, 2013 #Corresponding author
- Yoneshiro T, Ogawa T, Okamoto N, Matsushita M, Aita S, Kameya T, Kawai Y, Iwanaga T, Saito M. Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obesity 37: 993-998, 2013
- Yoneshiro T, Saito M. TRP-activated brown fat thermogenesis as a target of food ingredients for obesity management. Curr Opin Clin Nutr Metab Care 16: 625-631, 2013
- Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 24: 71-77, 2013
- Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, Iwanaga T, Kameya T, Kawai Y, Saito M. Grains of paradise (Aframomum melegueta) extract increase energy expenditure through the activation of brown adipose tissue in men. Br J Nutr 110: 733-738, 2013
- Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Non-pungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 95: 845-850, 2012
- Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K, Saito M, Saeki K. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 16: 394-406, 2012
- Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, Miyagawa M, Tsujisaki M, Saito M. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring) 19: 1755-1760, 2011
- Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M. Brown adipose tissue, whole-body energy expenditure and thermogenesis in healthy adult men. Obesity (Silver Spring) 19: 13-16, 2011
- Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58: 1526-1531, 2009
所属学会
日本肥満学会、日本栄養・食糧学会、日本生理人類学会、日本栄養改善学会、日本健康医学会、American Society for Nutrition