東京大学先端科学技術研究センター 代謝医学分野 酒井研究室

Home » メンバー » 米代武司

准教授 米代 武司(よねしろ たけし)

略歴

2007年3月 天使大学看護栄養学部 卒業
2010年3月 天使大学 看護栄養学研究科 博士前期課程 修了
2013年3月 北海道大学 医学研究科 博士課程 修了(博士(医学))
2012年4月 北海道大学 医学研究科 研究員(学振特別研究員)
2014年4月 北海道大学 獣医学研究科 研究員(学振特別研究員)
2016年7月 米国カリフォルニア大学サンフランシスコ校 糖尿病センター 研究員
(学振特別研究員・同海外特別研究員)
2020年4月 東京大学 先端科学技術研究センター 代謝医学分野 特任助教
2021年2月 東京大学 先端科学技術研究センター 代謝医学分野 助教
2022年4月 東京大学 先端科学技術研究センター 代謝医学分野 准教授 現在に至る

代表論文

  1. Yoneshiro T*, Wang Q*, Tajima K, Matsushita M, Maki H, Igarashi K, Dai J, White PJ, McGarrah RQ, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature 572: 614–619, 2019 *Equal contribution
  2. Yoneshiro T#, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M. Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest 123: 3404-3408, 2013 #Corresponding author

原著論文

  1. Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature, 2022
  2. Izawa S, Yoneshiro T, Kondoh K, Nakagiri S, Okamatsu-Ogura Y, Terao A, Minokoshi Y, Yamanaka A, Kimura K. Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure. J Physiol 600: 815-827, 2022
  3. Yoshida N, Yamashita T, Osone T, Hosooka T, Shinohara M, Kitahama S, Sasaki K, Sasaki D, Yoneshiro T, Suzuki T, Emoto T, Saito Y, Ozawa G, Hirota Y, Kitaura Y, Shimomura Y, Okamatsu-Ogura Y, Saito M, Kondo A, Kajimura S, Inagaki T, Ogawa W, Yamada T, Hirata KI. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience 24: 103342, 2021
  4. Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Elife 10: e66865, 2021
  5. Walejko JM, Christopher BA, Crown SB, Zhang GF, Pickar-Oliver A, Yoneshiro T, Foster MW, Page S, van Vliet S, Ilkayeva O, Muehlbauer MJ, Carson MW, Brozinick JT, Hammond CD, Gimeno RE, Moseley MA, Kajimura S, Gersbach CA, Newgard CB, White PJ, McGarrah RW. Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart. Nat Commun 12: 1680, 2021
  6. Nabatame Y, Hosooka T, Aoki C, Hosokawa Y, Imamori M, Tamori Y, Okamatsu-Ogura Y, Yoneshiro T, Kajimura S, Saito M, Ogawa W. Kruppel-like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes. J Diabetes Investig 12: 1144-1151, 2021
  7. Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nat Commun 12: 7045, 2021
  8. Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S. The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication. EMBO Rep 21: e49828, 2020
  9. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S.  CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell 182: 563-577.e520, 2020
  10. Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. Wireless optogenetics protects against obesity via stimulating non-canonical fat thermogenesis. Nat Commun 11: 1730, 2020
  11. Yoneshiro T*, Wang Q*, Tajima K, Matsushita M, Maki H, Igarashi K, Dai J, White PJ, McGarrah RQ, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature 572: 614–619, 2019 *Equal contribution
  12. Yoneshiro T*, #, Shin W*, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura K. Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation. FASEB J 33: 5196-5207, 2019 *Equal contribution, #Corresponding author
  13. Yoneshiro T#, Matsushita M, Saito M. Translational aspects of brown fat activation by food-derived stimulants. Handb Exp Pharmacol 251: 359-379, 2019 #Corresponding author
  14. Chen Y, Ikeda K, Yoneshiro T*, Scaramozza A*, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature 565: 180-185, 2019 (IF=43.070) *Equal contribution
  15. Tajima K, Ikeda K, Chang HY, Chang CH, Yoneshiro T, Oguri Y, Jun H, Wu J, Ishihama Y, Kajimura S. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nat Metab 1: 886–898, 2019
  16. Yoneshiro T, Kaede R, Nagaya K, Saito M, Aoyama J, Elfeky M, Okamatsu-Ogura Y, Kimura K, Terao A. Melinjo (Gnetum gnemon L.) seed extract stimulates brown fat thermogenesis and protects mice against obesity, inflammation, and insulin resistance. Nutr Res 58: 17-25, 2018
  17. Yoneshiro T, Kaede R, Nagaya K, Aoyama J, Saito M, Izawa S, Okamatsu-Ogura Y, Kimura K, Terao A. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obes Res Clin Pract 12: 127-137, 2018
  18. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of systemic succinate controls activation of adipose tissue thermogenesis. Nature 560: 102-106, 2018
  19. Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K. Suppression by adiponectin of late inflammatory mediator, HMGB1-induced cytokine expression in RAW 264 macrophage cells. J Biochem 163: 143-153, 2018
  20. Fuse S, Nirengi S, Amagasa S, Homma T, Kime R, Endo T, Sakane N, Saito M, Yoneshiro T, Kurosawa Y, Hamaoka T. Brown adipose tissue density and seasonal lower outdoor temperature in Japanese men and women with a wide range of age. J Biomed Opt 23: 1-9, 2018
  21. Lu X, Altshuler-Keylin S, Wang Q, Chen Y, Sponton CH, Ikeda K, Maretich P, Yoneshiro T, Kajimura S. Mitophagy controls beige adipocyte maintenance through a UCP1-independent mechanism. Sci Signal 11: 527, 2018
  22. Yoneshiro T#, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Katsuragi Y, Kameya T, Sugie H, Saito M. Tea catechin activates and recruits brown adipose tissue in humans. Am J Clin Nutr 105: 873-881, 2017 #Corresponding author
  23. Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P, Tajima K, Ajuwon KM, Soga T, Kajimura S. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med 23: 1454-1465, 2017
  24. Uchida K*, Dezaki K*, Yoneshiro T*, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki I. Involvement of thermo-TRP channels in energy metabolism. J Physiol Sci 67: 549-560, 2017 *Equal contribution
  25. Yoneshiro T#, Matsushita M, Nakae S, Kameya T, Sugie H, Tanaka S, Saito M. Brown adipose tissue determines seasonal changes in thermoregulatory responses to cold exposure in humans. Am J Physiol Regul Integr Comp Physiol 310: R999-R1009, 2016 #Corresponding author
  26. Saito M, Yoneshiro T, Matsushita M. Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans. Best Pract Res Clin Endoc Metab, 30: 537-547, 2016
  27. Nirengi S, Homma T, Inoue N, Sato H, Yoneshiro T, Tsuzaki K, Saito M, Sakane N, Kurosawa Y, Hamaoka T. Near-infrared time resolved spectroscopy assessment of changes in human brown adipose tissue density during repeated capsiate intake and intake cessation. J Biomed Opt 21: 091305, 2016
  28. Nirengi S, Yoneshiro T, Saiki T, Aita S, Matsushita M, Sugie H, Saito M, Hamaoka T. Evaluation of brown adipose tissue using near-infrared time-resolved spectroscopy. Adv Exp Med Biol 876: 371-376, 2016
  29. Nirengi S, Amagasa S, Homma T, Yoneshiro T, Matsumiya S, Kurosawa Y, Sakane N, Ebi K, Saito M, Hamaoka T. Catechin-rich beverage intake for 12 weeks increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women: a randomized controlled trial. SpringerPlus 5: 1363, 2016
  30. Hibi M, Oishi S, Matsushita M, Yoneshiro T, Yamaguchi T, Usui C, Yasunaga K, Kubota K, Tanaka S, Saito M. Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans. Int J Obesity 40:1655-1661, 2016
  31. Yoneshiro T, Saito M. Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. Ann Med 47: 133-141, 2015
  32. Saito M, Yoneshiro T, Matsushita M. Food ingredients as anti-obesity agents. Trends Endocrinol Metab 26: 585-587, 2015
  33. Nirengi S, Yoneshiro T, Sugie H, Saito M, Hamaoka T. A novel simple method for detecting brown adipose tissue using near-infrared time-resolved spectroscopy. Obesity (Silver Spring) 23: 973-980, 2015
  34. Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi K, Takagaki K, Kameya T, Sugie H, Saito M. Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. J Nutr Sci Vitaminol 61: 79-83, 2015
  35. Matsushita M, Yoneshiro T, Aita S, Kameya T, Sugie H, Saito M. Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans. Int J Obesity 38: 812-817, 2014
  36. Sugita J, Yoneshiro T, Sugishima Y, Ikemoto T, Uchiwa H, Iwanaga T, Suzuki I, Saito M. Daily ingestion of Grains of Paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J Nutr Sci Vitaminol 60: 22-27, 2014
  37. Yoneshiro T#, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M. Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest 123: 3404-3408, 2013 #Corresponding author
  38. Yoneshiro T, Ogawa T, Okamoto N, Matsushita M, Aita S, Kameya T, Kawai Y, Iwanaga T, Saito M. Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obesity 37: 993-998, 2013
  39. Yoneshiro T, Saito M. TRP-activated brown fat thermogenesis as a target of food ingredients for obesity management. Curr Opin Clin Nutr Metab Care 16: 625-631, 2013
  40. Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 24: 71-77, 2013
  41. Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, Iwanaga T, Kameya T, Kawai Y, Saito M. Grains of paradise (Aframomum melegueta) extract increase energy expenditure through the activation of brown adipose tissue in men. Br J Nutr 110: 733-738, 2013
  42. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Non-pungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 95: 845-850, 2012
  43. Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K, Saito M, Saeki K. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 16: 394-406, 2012
  44. Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, Miyagawa M, Tsujisaki M, Saito M. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring) 19: 1755-1760, 2011
  45. Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M. Brown adipose tissue, whole-body energy expenditure and thermogenesis in healthy adult men. Obesity (Silver Spring) 19: 13-16, 2011
  46. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58: 1526-1531, 2009

所属学会

日本肥満学会、日本栄養・食糧学会、日本生理人類学会、日本栄養改善学会、日本健康医学会、American Society for Nutrition

↑このページの先頭へ